Evans blue
CAS No. 314-13-6
Evans blue( —— )
Catalog No. M14013 CAS No. 314-13-6
Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 37 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 72 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEvans blue
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NoteResearch use only, not for human use.
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Brief DescriptionEvans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
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DescriptionEvans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively).
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In Vitro——
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In VivoAnimal Model:CD-1 mice bearing intracerebral hemorrhage (ICH)Dosage:2% solution; 4 mL/kg Administration:Jugular vein or intraperitoneal injection; once Result:Showed the amount of stain accumulated in the brains.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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Recptorvesicular glutamate uptake
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number314-13-6
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Formula Weight960.78
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Molecular FormulaC34H24N6Na4O14S4
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Purity>98% (HPLC)
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SolubilityWater: 10 mM
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SMILESCC1=C(C=CC(=C1)C2=CC(=C(C=C2)N/N=C\3/C(=O)C4=C(C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C3)C)N/N=C\5/C(=O)C6=C(C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C5.[Na+].[Na+].[Na+].[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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(R)-ADX-47273
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
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DMeOB
DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and can be used to study neurological diseases.
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